Artichoke Spinach Grilled Cheese

Featured in: Easy Weeknight Meals

Transform your grilled cheese experience with this elevated spinach-artichoke variation. Creamy cheese and artichoke hearts blend seamlessly with fresh spinach and garlic, creating a luxurious filling that melts beautifully between crispy sourdough slices.

The key is mixing your filling thoroughly before assembly, using softened butter for even browning, and cooking over medium heat to ensure the bread turns golden while the cheese reaches perfect meltiness. Press gently during cooking for even contact.

Serves four and takes just 25 minutes total. Pairs wonderfully with tomato soup or a fresh green salad for a complete meal.

Updated on Tue, 20 Jan 2026 12:04:00 GMT
Golden, crispy sourdough slices encasing a warm, melted spinach-artichoke grilled cheese, perfect for dipping in tomato soup.  Pin
Golden, crispy sourdough slices encasing a warm, melted spinach-artichoke grilled cheese, perfect for dipping in tomato soup. | quickcrav.com

The smell of garlic and butter browning in a skillet still brings me straight back to a cold Thursday evening when I stood at the stove, craving comfort and something more interesting than plain cheese. I had leftover spinach-artichoke dip in the fridge and a hunch it would melt beautifully between two slices of sourdough. That hunch turned into one of my most-requested sandwiches. It's rich, creamy, and just indulgent enough to feel like a treat without requiring any real effort.

I made this for my sister one afternoon when she stopped by unannounced, tired and hungry. She took one bite, closed her eyes, and said it tasted like a fancy café sandwich but better because it was warm from my kitchen. We sat at the counter with our sandwiches and mugs of tomato soup, catching up between bites. That's when I realized this recipe wasn't just about the cheese or the artichokes, it was about making something that felt generous and easy at the same time.

Ingredients

  • Fresh spinach, chopped: Fresh spinach wilts into the filling beautifully, but frozen works too as long as you squeeze out every bit of water so the mixture doesn't get soupy.
  • Artichoke hearts, drained and chopped: Canned or jarred artichokes add tangy, tender bites throughout the sandwich, and chopping them small helps them spread evenly.
  • Cream cheese, softened: This is the creamy base that holds everything together and makes the filling luscious instead of dry.
  • Shredded mozzarella cheese: Mozzarella melts into stretchy, gooey strands that make every bite satisfying.
  • Shredded Monterey Jack or Swiss cheese: Monterey Jack is mild and melty, while Swiss adds a slight nuttiness, either one works perfectly.
  • Grated Parmesan cheese: A little Parmesan brings a salty, savory depth that balances the creaminess.
  • Unsalted butter, softened: Butter on the outside of the bread creates that golden, crispy crust we all crave in a grilled cheese.
  • Sourdough bread: Sourdough has the right balance of chew and structure to hold up to a rich filling without getting soggy.
  • Garlic clove, minced: Fresh garlic gives the filling a warm, aromatic kick that makes the whole sandwich smell incredible.
  • Black pepper: A little pepper brightens the flavors and cuts through the richness just enough.
  • Crushed red pepper flakes: Optional, but a pinch adds a subtle heat that makes the sandwich more interesting.
  • Pinch of salt: Just enough to bring all the flavors into focus without overpowering the cheeses.

Instructions

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Mix the filling:
In a mixing bowl, stir together the cream cheese, mozzarella, Monterey Jack, Parmesan, spinach, artichokes, garlic, black pepper, red pepper flakes, and a pinch of salt until everything is well blended and creamy. The mixture should be thick enough to spread but not crumbly.
Assemble the sandwiches:
Lay out all eight slices of sourdough and spread the artichoke-spinach mixture evenly onto four of them. Top each with another slice of bread to form four sandwiches.
Butter the outsides:
Spread softened butter lightly on the outside of each sandwich, covering both the top and bottom slices. This is what creates that golden, crispy crust.
Grill until golden:
Heat a large skillet or griddle over medium heat and place the sandwiches in the pan. Cook for 3 to 4 minutes per side, pressing gently with a spatula, until the bread is golden brown and the cheese inside is melted and gooey.
Rest and serve:
Remove the sandwiches from the skillet and let them rest for about a minute before slicing. This helps the filling set just enough so it doesn't all spill out when you cut in.
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Air fry, roast, reheat, and dehydrate meals quickly for crispy snacks and easy weeknight dinners.
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Artichoke Spinach Grilled Cheese sandwich with a creamy, gooey filling, served on a rustic wooden cutting board.  Pin
Artichoke Spinach Grilled Cheese sandwich with a creamy, gooey filling, served on a rustic wooden cutting board. | quickcrav.com

One night I made these for a small group of friends who came over to watch a movie, and I sliced each sandwich into halves and stacked them on a plate. Everyone grabbed one without much thought, but halfway through the film I noticed the plate was empty and people were asking if there were more. It became clear that this wasn't just a sandwich, it was the kind of thing people remember and request again.

Choosing Your Bread

Sourdough is my go-to because it has a sturdy crumb and a slight tang that complements the creamy filling, but I've also used whole wheat for a heartier bite and even gluten-free bread when cooking for friends with dietary restrictions. The key is to pick something with enough structure to hold the filling without falling apart. Avoid soft sandwich bread, it tends to get soggy and doesn't crisp up as well in the pan.

Making It Ahead

The artichoke-spinach filling can be made up to two days in advance and stored in an airtight container in the fridge, which makes weeknight cooking much easier. I like to prep the filling on a Sunday and then just assemble and grill the sandwiches when I need them. The flavors actually deepen a bit after sitting, and the garlic mellows into something even more delicious.

Serving Suggestions

This sandwich pairs beautifully with a bowl of warm tomato soup, which you can dip the crispy edges into, or a simple green salad dressed with lemon and olive oil to balance the richness. I've also served it alongside roasted sweet potato wedges or a handful of kettle chips when I want something quick and satisfying. It's hearty enough to be the main event but also works well as part of a casual spread.

  • Add a few chopped sun-dried tomatoes or scallions to the filling for extra flavor and color.
  • Try different cheeses like Gruyere or sharp cheddar if you want to change up the taste.
  • If you like a little crunch, toss some toasted pine nuts or chopped walnuts into the filling before assembling.
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Buttery, golden-brown Artichoke Spinach Grilled Cheese slices reveal melted mozzarella and Monterey Jack inside. Pin
Buttery, golden-brown Artichoke Spinach Grilled Cheese slices reveal melted mozzarella and Monterey Jack inside. | quickcrav.com

This sandwich has become one of those recipes I turn to when I want something comforting, quick, and just a little bit special. I hope it finds a spot in your kitchen the way it has in mine.

Recipe Q&A

Can I prepare the filling ahead of time?

Yes, the artichoke-spinach filling can be made up to 2 days in advance and stored in an airtight container in the refrigerator. Simply spread it onto your bread when ready to cook.

What's the best bread choice for this sandwich?

Sourdough is ideal for its sturdy texture and tangy flavor that complements the creamy filling. You can also use whole wheat bread for added fiber or gluten-free varieties depending on your dietary needs.

How do I prevent the bread from burning before the cheese melts?

Cook over medium heat rather than high, which allows the cheese to melt gradually as the bread browns. Pressing gently during cooking helps distribute heat evenly without scorching the exterior.

What cheeses work best for this combination?

The blend of mozzarella, Monterey Jack or Swiss, and Parmesan creates optimal melting and flavor. Mozzarella provides stretch, Monterey Jack adds creaminess, and Parmesan contributes a subtle sharpness that balances the filling.

Can I add other ingredients to the filling?

Absolutely. Sun-dried tomatoes, chopped scallions, roasted red peppers, or caramelized onions all enhance the filling beautifully. Keep proportions balanced so the mixture spreads evenly without becoming too wet.

Is there a dairy-free version possible?

You can substitute cream cheese with dairy-free alternatives and use plant-based cheese blends, though the melting and flavor profile will differ. The cooking technique remains the same.

Artichoke Spinach Grilled Cheese

Golden sourdough sandwich filled with creamy spinach-artichoke dip and melted cheese blend. A gourmet comfort food ready in 25 minutes.

Preparation time
15 min
Cooking time
10 min
Total time
25 min


Difficulty Easy

Origin American

Yield 4 Servings

Dietary specifications Vegetarian

Ingredients

Vegetables

01 1 cup fresh spinach, chopped (or 1/2 cup frozen, thawed and drained)
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 1/2 cup shredded mozzarella cheese
03 1/2 cup shredded Monterey Jack or Swiss cheese
04 1/4 cup grated Parmesan cheese
05 2 tablespoons unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 1/4 teaspoon black pepper
03 1/8 teaspoon crushed red pepper flakes (optional)
04 Pinch of salt

Instructions

Step 01

Prepare the filling: In a mixing bowl, combine cream cheese, mozzarella, Monterey Jack or Swiss cheese, Parmesan, spinach, artichokes, garlic, black pepper, red pepper flakes, and salt. Mix until well blended.

Step 02

Assemble sandwiches: Lay out sourdough slices. Spread artichoke-spinach mixture evenly onto 4 slices. Top with remaining bread slices to form sandwiches.

Step 03

Butter the sandwiches: Lightly butter the outside of each sandwich on both sides.

Step 04

Cook the sandwiches: Heat a large skillet or griddle over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 05

Rest and serve: Remove from skillet, let rest 1 minute, then slice and serve warm.

Required equipment

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergen information

Review each ingredient to identify potential allergens and seek advice from a healthcare professional if uncertain.
  • Contains dairy (cheese, butter) and wheat (bread)
  • May contain soy depending on bread and cheese brands
  • Check labels for potential cross-contamination if allergies are severe

Nutritional values (per serving)

These details are offered as a general guide only and shouldn't replace professional medical guidance.
  • Calories: 410
  • Fat: 23 g
  • Carbs: 38 g
  • Protein: 15 g